Hello, How Does ISRIB Compare To Nootropics? This is my second guest post being published here. It’s by Robert Jila. A man that I recently came into contact with after publishing my recent review on the Cogniora Nootropics. He messaged me to ask if I’d heard of ISRIB so I asked him back if he would like to write this guest post.
Less than a week later. Here it is…
How Does ISRIB Compare To Nootropics?
#Di4L Guest Post by Robert Jila
How Does ISRIB Compare To Nootropics?
Introducing Robert Jila…
My name is Robert Jila, I’m from Ukraine. I am 25 years old and I’ve used to work in the chemical sphere for 5 years. Today I would like to tell you about an amazing substance ISRIB, which can make better a lot of lives. ISRIB is often compared with drug NZT-48 from the movie ‘Limitless‘.
I have been interested in ISRIB for many years but decided to apply it about a year ago. The result is incredible. Using of ISRIB regularly helped me to get rid of brain fog and lack of concentration. I can work much harder and more effectively than before. I have started to do sports and got a lot of motivation. So I think it would be interesting for many readers.
What is ISRIB?
ISRIB – is an inhibitor of low ISR (integrated stress response). The integrated stress response (ISR) protects cells from a variety of harmful stressors by temporarily halting protein synthesis. Every single cell is a very complex machine. For most of its functions, it synthesizes a wide variety of proteins.
Stopping protein synthesis means stopping the functioning of the cell. In this case, the cell remains in limbo, and the functions performed by it are significantly reduced. Protein synthesis is a very hard and complex procces, so it can be regulated by different internal and external factors. One key in the protein synthesis is eukaryoitic initiation factor 2 (eIF2), wich can be phosphorylated by different stressors.
If eIF2 is phosphorylated – protein synthesis stops. ISR mediate this phosphorylation of eIF2. However, ISR can be activated by a huge variety of stressors: amino acid deprivation, endoplasmic reticulum stress, heme deprivation, presence of heavy metals, viral infection, hypoxia and etc.
After prolonged ISR, there can be triggered apoptosis (programmed cell death) in the cell. On the other hand, DE phosphorylation of eIF-2 renews protein synthesis in the cell. ISR phosphorylation and DE phosphorylation in the cell regulate normal cell life.
Recovering From Traumatic Brain Injury
There are a lot of problems in recovering from traumatic brain injury. The problem is that during a stroke, cells are put under stress. They are in limbo and due to the long-term functioning of the ISR, cells cannot return to normal functioning and this is the biggest problem during brain recovery after a stroke.
ISRIB inhibits ISR and restores the normal functioning of cells. eIF-2 plays a special role in the formation and consolidation of memory in the hippocampus. For normal memory formation, cells need good proteostasis. Inhibition of eIF-2 through mutations increased cognition in mice.
Moreover, Isrib restores both short-term and long-term memory. ISRIB restores LTP (long term potentiation), increases cognitive abilities in both sick and healthy.
So now we know what ISR is and we will return to ISRIB. Again, ISRIB inhibits low-stress response, that is present in our everyday life. Interestingly, low activation of ISR is very toxic in the long term throughout our life. The integrated response to low stress is essentially the limiter of our energy potential.
What Effects Do You Feel After Using ISRIB?
ISRIB improves the cognitive abilities of the brain. In about 15 minutes after intake (internasal) you start to feel some kind of lightness in your head and body. Your thinking becomes faster and faster in geometrical progression, (visual) shapes of things become more recognizable, cornered. Tastes and smells start to be much more strong.
So it’s raising concentration, memory and thinking. ISRIB helps to solve difficult tasks and to study. If you have to learn a lot of new information, ISRIB is the best for help. You’re controlling your emotions to be focused and productive. You become more active during the day and have to sleep less than usual.
Less Sleep Needed?
Speaking about sleeping, 4-6 hrs/day is enough, you start to eat so much that your fridge will be shocked. Your cognitive and physical stats rise like never before. It regenerates neurons in the brain so everyone can feel positive effects.
Unlike other nootropics, ISRIB boosts your brain more for multiple days at a time without any negative post or side effects. This incredible substance can help to fight such serious diseases as dementia, Parkinson’s and Alzheimer’s. ISRIB is good at the recovering brain after insult attacks and mechanical injuries.
How to Use it?
You can use ISRIB with a dosage of 15-30mg orally. It can be variable due to the weight and age of every person. The bigger dose is bigger effects. Also for greater efficiency, it is possible to use it intravenously 5mg ISRIB per 0.5ml DMSO + 0.5ml PEG-400.
There’s no strict validity period. Positive influence is visible on the next days too. You can use ISRIB on an everyday occasion. It’s good to make courses of usage for 3 weeks and then after the break(nearly 2 weeks) to repeat the course again. Alcohol does not take you so strong if you under ISRIB.
The lowest prices and good quality to buy ISRIB you can find on the https://www.isrib.shop/
YOUR FEEDBACK
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Best Regards and Stay Dynamic
Alex B. Chivers
DynamicIdeas4Life
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About Author
Have you ever thought about including a little bit more than just your articles?
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Yes I get what you mean. A lot of blog posts on here need some serious work doing to them. I do have this in the back of my mind. Thanks for taking the time out your day to comment.
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Thank you.