Managing Blood Sugar Naturally has become a major focus in 2025, and many people now turn to supplements for extra support. But with so many products claiming to help, it can be hard to separate what works from what doesn’t.

In this updated guide, we rank the Best and Worst Supplements for Blood Sugar Support in 2025, based on research, safety, user reviews, long-term effectiveness, and value for money. If you’re looking for supplements that may genuinely support healthy glucose levels—and want to avoid the ones that don’t—this list we hope will help you make smarter choices.

***Note Before Purchasing Any Dietary Supplements – Always consult with a medical professional before beginning to take any new supplements<<< Some supplements can contain Ingredients that may be unsafe when taken with medication for example.

We hope though that you can find this breakdown of different products beneficial for your personal needs.

***Updated Guide Best Blood Sugar Support Supplements for 2026!***

Who Are Blood Sugar Support Supplements For?

---

Supplements for Blood Sugar Support can be taken by any individuals who are looking to better manage their blood sugar levels and support overall metabolic health. These supplements are most commonly used by:

1. People with Prediabetes…
   In this situation Supplements can help stabilize blood sugar levels in those at risk of developing type 2 diabetes. Combined with a balanced diet and regular physical activity, they may aid in delaying or even preventing the onset of diabetes.
2. Individuals with Type 2 Diabetes…
   For those already diagnosed with type 2 diabetes, supplements may complement prescribed medications and lifestyle changes. They can assist in improving insulin sensitivity and reducing post-meal blood sugar spikes, potentially enhancing overall glycaemic control.
3. Those Managing Insulin Resistance…
   People experiencing insulin resistance, whether due to metabolic syndrome or other conditions, may benefit from supplements that support better glucose uptake by cells and improve metabolic balance.
4. Individuals Focused on Preventive Health…
   Even those without a diagnosis of diabetes or prediabetes may use blood sugar support supplements to maintain healthy glucose levels, particularly if they are at higher risk due to genetics, diet, or lifestyle factors.
5. Older Adults or Those with Changing Metabolism…
   Aging can affect how the body processes glucose. Some older adults find supplements helpful in maintaining balanced blood sugar levels as part of their overall health strategy.

Important Considerations:

• Consultation First: It’s essential to talk to a healthcare provider before starting any supplement, especially for those on medications or managing chronic health conditions.
• Not a Replacement: Supplements are designed to support—not replace—medical treatments, medications, or lifestyle changes prescribed by a doctor.
• Tailored Approach: The choice of supplements should be based on individual health needs, existing conditions, and personal health goals.

By integrating the right supplements into a comprehensive health plan, individuals can take proactive steps to better manage their blood sugar levels and overall health.

So, let’s begin, here is our ever growing list of supplements that we would like to share with you for Blood Sugar Support and Diabetes

#3.)  Touchstone Essentials Gluco Control

---

Company:  Touchstone Essentials
Owners:  Eddie Stone
Based In:  USA
Rating:  4.2 Stars out of 5

Website:  https://TheGoodInside.com/GlucoControl

How Much To Buy:  $75.00 (1 Bottle)

About Touchstone Essentials Gluco Control

Gluco-Control is a natural blood sugar support supplement from Touchstone Essentials. It is formulated to help reduce glucose spikes after meals and improve metabolic health. According to Touchstone, its formula combines glucose-converting plant enzymes, organic mushrooms, and probiotics to support healthier blood sugar regulation.

Warranty:   180 Days

Ingredients:  

SUGASEB, HEMISEB, Sucrase, Alpha Amylase, Protease I, Lipase, Protease IV, Lactase, Protease II, Cellulase, Alpha Galactosidase, Beta Amylase, Organic Gum Acacia, Chaga Mushroom (organic extract), Reishi Mushroom (organic extract), Lactobacillus gasseri, Lactobacillus fermentum, Lactobacillus plantarum, Organic rice extract blend  and Capsule shell: Non-GMO plant cellulose (vegetarian capsule)

How It Works?

• Contains plant-based enzymes that convert digestible glucose into a resistant starch form, reducing the amount of glucose released into the bloodstream.
• Includes organic mushrooms + probiotics, which may support gut health and metabolic function.
• Helps flatten the glucose curve: by reducing the magnitude of post-meal glucose spikes, it aims to reduce the “crash” that can lead to cravings and overeating.
• The suggested use is 1–2 capsules about 1 hour before a main meal for optimal glucose-support effects.

Research Summary

---

Research	Source
The formula is based on a “breakthrough” discovery of a plant enzyme complex that can convert glucose into a form that is more slowly absorbed, thereby helping to modulate blood sugar at the point of digestion.	The Food Institute
By converting some of the glucose into resistant starch, Gluco-Control may reduce postprandial (after-meal) blood sugar spikes, which is a key driver of insulin demand.	Clemson HGIC
Its combination of mushrooms and probiotics suggests an additional mechanism via gut health, which is increasingly recognized as important for metabolic regulation.	ScienceDaily
According to the user guidance, regular use may promote feeling fuller for longer, help curb sugar cravings, and support more stable blood sugar levels.	TheGoodInside
As of its launch (2023), it is a relatively new product, so long-term clinical research specific to the supplement itself may be limited, but the constituent ingredients (enzymes, probiotics, glucose-converting molecules) are based on emerging science.	TheGoodInside

Pros and Cons

---

Pros	Cons
✔ Innovative mechanism — uses a plant enzyme to convert glucose, not just reduce absorption.	✖ Because the mechanism relies on digestive conversion, its effectiveness may vary depending on individual gut health.
✔ Combined gut support — includes mushrooms and probiotics, which may improve metabolic health via the microbiome.	✖ Must be taken before meals to work, which adds planning.
✔ Vegan / Non-GMO / Gluten-free — accessible to a wide range of users.	✖ May be less potent for very high blood glucose compared to berberine-based formulas.
✔ Flexible dosing — 1 or 2 capsules before meals depending on your needs.	✖ Relatively new: limited long-term clinical data on this exact formulation (rather than the individual ingredients).
✔ May reduce cravings and hunger — by smoothing out glucose peaks and troughs.	✖ As with any “metabolism / blood sugar” supplement, there’s potential for interactions with medications (e.g., insulin or glucose-lowering drugs) — medical supervision advised.
✔ Clean branding — Touchstone Essentials is known for its clean-label, natural-ingredient philosophy.

Who Is It For?

---

Best For	Avoid If
People who want to prevent or reduce post-meal blood sugar spikes (rather than relying purely on insulin sensitivity).	You have poor digestion or gastrointestinal issues — the enzyme-based mechanism may not work optimally in all people.
Individuals who prefer a natural, enzymatic approach over more aggressive glucose-lowering herbs.	You have diabetes that requires tight blood sugar control via medication (always check with a healthcare provider before combining).
Those who are conscious about gut health and want metabolic support + microbiome support in one supplement.	You prefer very high-potency glucose-lowering herbal supplements like pure berberine.
Anyone who finds that cravings after meals are a major challenge.	You are very sensitive to supplement timing — since this needs to be taken before meals, lifestyle restrictions may make it inconvenient.
People looking for a clean-label, vegan supplement.	You don’t like to take capsules before food (because of the timing requirement).

My Verdict:  Try Gluco-Control to help flatten your post-meal glucose spikes, reduce cravings, and support steadier energy — take 1–2 capsules about an hour before your main meals. (Visit The Touchstone Essentials Website HERE<<)

>>Also, if you are Interested you can Read my original review here<<<

#5.)  GlucoseMD

---

Company:  Healthy 1MD Nutrition®
Owners:  Ziv Haklili and Ben Flohr
Based In:  Irvine, California
Rating:  4 out of 5 Stars

Website:   https://1md.org/products/glucosemd

How Much To Buy:  Prices Start at $54.00 a bottle but you can get further reductions buying as a 3 or 6 Pack and by Subscribe and Save

Money-Back Guarantee:  90 Day Money Back Guarantee

About Glucose MD

GlucoseMD is a doctor-formulated supplement from 1MD Nutrition, designed to support healthy blood glucose levels, metabolic function, and cardiovascular health. The formula includes a powerful blend of berberine, patented cinnamon extract (CinSulin®), gymnema, chromium, lion’s mane mushroom, cayenne, and neem leaf.

Ingredients:  Chromium Picolinate, CinSulin, Lion’s Mane (Fruit Body), Neam Leaf, Cayenne Pepper, Gymnema Leaf and Stem, Berberiene HCL

How It Works

• Neem Leaf provides anti-inflammatory and metabolic support, potentially helping with glucose regulation.
• Berberine activates AMPK, helping to improve insulin sensitivity and support glucose uptake.
• CinSulin® (cassia cinnamon extract) is a water-soluble form of cinnamon that supports glucose metabolism and helps maintain healthy blood sugar levels.
• Gymnema helps reduce sugar absorption in the gut and may help suppress sweet cravings.
• Chromium is a trace mineral that supports insulin signalling and helps cells more effectively take up glucose.
• Lion’s Mane Mushroom is included for its unique metabolic effects; 1MD claims it blocks a “specific enzyme” in carb digestion to slow glucose breakdown.
• Cayenne (Capsicum) helps support metabolism and may assist with energy regulation.

Research Summary

---

Research	Source
1MD’s own description says GlucoseMD was formulated to slow the breakdown of glucose in the gut, support pancreatic function, and promote efficient glucose absorption.	1md.org
Berberine has strong clinical research supporting its effect on glucose control, especially through AMPK activation.	ScienceDirect
CinSulin®, the patented cinnamon extract, is based on water-soluble cinnamon polyphenols — these have been studied for glucose metabolism.	1md.org
Chromium also has a body of evidence supporting its role in enhancing insulin action (though results are mixed depending on dose and form).	ScienceDirect
Gymnema has traditional and some clinical backing for reducing sugar absorption.	ResearchGate
Lion’s Mane’s role in blood sugar control is less well studied, especially for glucose-lowering — the claim about “blocking a digestion enzyme” comes from 1MD’s own description, not large-scale clinical trials.	1md.org

Pros and Cons

---

Pros	Cons
✔ Well-rounded formula: hits multiple mechanisms (absorption, sensitivity, metabolism)	✖ High chromium dose: at 600 mcg according to HelloPharmacist, which is a very high % of daily value and could be a risk if overused.
✔ High-dose berberine (500 mg), which is effective for many users.	✖ Potential drug interactions: Berberine, chromium, and other ingredients can interact with blood-sugar-lowering medications — must check with a healthcare provider.
✔ Patented CinSulin® cinnamon extract — more reliable active compounds than standard cinnamon.	✖ Results may take time: as with most metabolic supplements, consistent daily use (and lifestyle changes) seems necessary.
✔ Doctor-endorsed: formulated with input from Dr Heather Shenkman, a cardiologist.	✖ Relatively expensive, especially for a two-capsule daily dose.
✔ Vegan & non-GMO, according to 1MD.	✖ Unclear long-term effects of some ingredients at the doses used (especially Lion’s Mane for blood sugar).
✔ Supports cardiovascular health in addition to glucose — useful for metabolic syndrome type risk.	✖ Not a substitute for medication in people with very high blood sugar or diabetes — more of a support than a treatment.

Who Is It For?

---

Best For	Avoid If
People who want a multi-mechanism supplement (not just berberine) for glucose support.	You are on strong diabetes medication (insulin, sulfonylureas, etc.) unless cleared by your doctor.
Users who are concerned about both blood sugar and cardiovascular health.	You have sensitivity to chromium or have had issues with mineral supplements.
Those comfortable taking two capsules per day with food.	You are pregnant or breastfeeding — safety of some of these herbal extracts in pregnancy is uncertain.
Individuals who prefer clinically studied extracts like CinSulin® cinnamon.	You don’t like taking more than one or two capsules a day.
Anyone willing to commit to consistent use (3+ months) to assess effects.	You expect rapid blood sugar reductions — this is a supportive supplement, not a drug.

#6.)  CarboFix Carbohydrate Management Formula

---

Company:  Gold Vida
Owners:  Matt Stirling
Based In:  London, Ontario, Canada
Rating:  3.0 out of 5 Stars 

Website:  theCarbofix.com  

How Much To Buy:  $49.00 (1 Bottle), $39.00 ea. (If bought as 3 Pack), $34 (If bought as 6 Pack)

Money-Back Guarantee:  60 Days from Date of Purchase

About CarboFix

CarboFix is a metabolism and glucose support supplement designed around AMPK activation, featuring cinnamon extract, chromium, berberine, alpha-lipoic acid, and benfotiamine.

Ingredients: 

Chromium Picolinate, Berberine HCL, Cinnamon Bark, ALA (Alpha Lipoic Acid), Benfotiamine, Naringin (from Grapefruit)

How It Works

• Benfotiamine may protect against oxidative stress
• Berberine + Cinnamon help support insulin sensitivity
• Chromium aids glucose transport
• ALA may support mitochondrial energy metabolism

Research Summary

---

Research	Source
Berberine, ALA, cinnamon extract, and chromium have independent human clinical research supporting their potential metabolic and blood sugar benefits.	NIH
Benfotiamine has research related to diabetic nerve and metabolic health, not glucose-lowering directly.	ResearchGate
Naringin research remains limited, mostly animal or cellular studies.	ScienceDirect
Mechanistic support for AMPK activation exists — mostly through berberine and naringin	ScienceDirect

Pros and Cons

---

Pros	Cons
✔ Multi-pathway metabolic support	✖ Marketing can feel “fat-loss focused,” not medical
✔ Good ingredient diversity	✖ Some users may dislike multi-capsule dosing
✔ May support weight management in addition to glucose	✖ Not ideal for stimulant-sensitive individuals
✔ Transparent labeling

Who Is It For?

---

Best For	Avoid If
✅ Individuals seeking glucose + metabolism + weight support in one formula	⛔ You’re on prescription diabetes medication without physician approval
✅ People with high-carb diets or noticeable post-meal glucose spikes	⛔ You take medications affected by grapefruit/naringin metabolism
✅ Supplement users who want AMPK-focused formulations	⛔ You’re pregnant, breastfeeding, or under 18
✅ Those who prefer herbal + nutritional blends rather than single-ingredient supplements	⛔ You expect drug-like or rapid blood sugar changes
	⛔ You dislike supplements marketed for weight loss

#7.)  Pure Health Research Blood Sugar Formula

---

Company:   Pure Health Research
Owners:  Dr. Holly Lucille, ND, RN, 
Based In:  Arlington, Virginia, USA
Rating:  3.75/5 

Website:  https://www.purehealthresearch.com

How Much To Buy:  $69.00 (1 Bottle, 30 Capsules), $59.00 (If Bought as 3 Pack), $53.00 (If Bought as 6 Pack)

About Pure Health Research Blood Sugar Formula

A botanical blend featuring berberine, cinnamon, bitter melon, turmeric, ginger, fenugreek, gymnema, and vanadium, marketed for balanced glucose, carb control, and metabolic wellness.

Ingredients:  

Vitamin C (as ascorbic acid), Vitamin E (d-alpha Tocopheryl Acetate), Magnesium (as citrate), Zinc (as citrate), Manganese (as amino acid chelate), Chromium (as picolinate), L-Taurine, Vanadium (as vanadyl sulfate), Proprietary Blend: Ceylon Cinnamon (bark), DGL Licorice Extract (root), Berberine HCL 97%, Alpha Lipoic Acid, Cayenne Pepper (fruit), Bitter Melon (fruit), Guggul (fruit), Yarrow (root), Mulberry (leaf).

How It Works

Targets blood sugar through:

• Digestive/metabolic support (ginger, turmeric)
• Improved insulin response (berberine, gymnema)
• Reduced post-meal spikes (cinnamon, fenugreek)

Research Summary

---

Research	Source
PureHealth’s website provides clinical references for many of the formula’s ingredients, including studies on Vitamin C, chromium, zinc, and vanadium.	Pure Health Research
Vitamin C: Some research suggests that people with diabetes may have lower circulating ascorbic acid levels, and supplementation could help.	Oxford Academic
Vanadium: The company cites research on vanadium (specifically vanadyl compounds) showing potential to enhance glucose uptake and mimic insulin activity in early-stage studies.	NIH
Chromium: Widely studied for its role in insulin signaling; though results vary depending on form and dose.	Asian Institute of Research
Antioxidants (Vitamins C and E): These are included not just for sugar control, but to help protect cells from the oxidative stress associated with metabolic imbalance.	ScienceDirect

Pros and Cons

---

Pros	Cons
✔ Very well-rounded: combines vitamins + minerals + trace elements — not just herbs.	✖ Because doses per ingredient seem relatively moderate, it may not be very potent for people with significant blood sugar dysregulation.
✔ Focus on metabolic health, not just “blood sugar lowering.”	✖ No clinical trials using the exact formula — effectiveness is inferred from ingredient-level research.
✔ Manufactured in a GMP-certified facility.	✖ Results likely take time and consistency; may not deliver quick, dramatic effects.
✔ 365-day money-back guarantee — very generous trial period.	✖ Some users report mild digestive issues like bloating.
✔ Ethical/social impact — every purchase contributes to child nutrition programs via Vitamin Angels.	✖ Not specifically targeted at post-meal blood sugar spikes — more about metabolic support than “spike control.”
✔ Non-GMO ingredients.	✖ May interact with other metabolic supplements or medications; always talk to a healthcare provider.

Who Is It For?

---

Best For	Avoid If
People who want gentle, long-term metabolic support rather than aggressive glucose-lowering.	You are on prescription diabetes medication (unless your doctor approves combining)
Individuals who prefer a vitamin/mineral-based formula to herbal-only supplements.	You need a powerful glucose-lowering effect (this is more supportive than therapeutic)
Those who like the idea of social impact — buying supports child nutrition programs.	You have a known allergy to any of the included minerals (chromium, zinc, etc.)
Users who want a supplement to complement healthy lifestyle habits, not replace medication.	You are pregnant or breastfeeding — safety of such combined supplements should be checked with a healthcare provider
People who prefer non-proprietary, transparent nutrient blends.	You prefer formulas with potent herbal extracts rather than vitamins/minerals

✅ For those looking for a science-backed, nutrient-rich supplement that supports stable energy, metabolic balance, and long-term glucose health – Pure Health Research Blood Sugar Formula is a balanced, ethically minded choice — and backed by a 365-day guarantee.

VIII.)  MD Process GlucoBerry

---

Company:  MD Process
Owners:  Dr. Mark Weis, MD
Based In:  (GlucoBerry “made in a USA, GMP certified facility”).
Rating:  3.1 Stars According to Amazon

Other Products:  No other known products by company

Website:  https://bloodsugarberry.com/

How Much To Buy:  According to the official website 1 bottle (30 capsules) listed at US $59 ~ 3‐bottle package ~ US $147 (~US$49 each) • 6‐bottle option $39 each ($234 USD)

Description:  GlucoBerry is marketed as a dietary supplement formulated “to support healthy blood sugar levels” by helping what is described as the body’s “Blood Sugar Drain” (a kidney‑filtration system concept) and using plant‑based extracts (especially maqui berry) plus chromium, biotin and gymnema leaf. The product states you take one capsule daily, preferably with food in the morning.

Warranty:  180 Days The “warranty” (better called refund/guarantee) is a 180‑day money‑back guarantee according to multiple sources (e.g., “you can return even empty bottles within 180 days for a full refund”).

Ingredients:   The formula includes: • Maqui Berry Extract (star ingredient) — described as antioxidant‑rich, supporting the “blood sugar drain”.• Gymnema Sylvestre Leaf extract — to reduce sugar cravings and support insulin function. Chromium (often in picolinate form) — to help insulin sensitivity. • Biotin (vitamin B7) — to support carbohydrate metabolism. •

How It Works

• Maqui Berry Extract (Delphinol®): The star ingredient. Rich in delphinidins (a type of anthocyanin), which MD/Process claims help dissolve sticky proteins (SG2) that can impair the kidney’s ability to drain excess glucose.
• Chromium: A trace mineral that supports insulin sensitivity and helps insulin more effectively transport glucose into cells, and aids in metabolic regulation.
• Biotin (Vitamin B7): Helps with carbohydrate metabolism and energy production, supporting the conversion of glucose into usable energy.
• Gymnema Sylvestre Leaf: A traditional herb used for blood sugar balance. It may help reduce sugar cravings and support healthy glucose regulation.

The idea is that by supporting the kidney’s “sugar drain”, GlucoBerry helps the body eliminate excess glucose rather than only relying on insulin or limiting absorption.

Research Summary

---

Research	Source
MD/Process cites clinical research on maqui berry extract (Delphinol®) showing that it can reduce post-meal blood glucose levels.	bloodsugarberry.com
According to their own data, daily use of the berry extract has been linked to improvements in long-term glucose markers.	bloodsugarberry.com
The chromium + biotin combination in GlucoBerry is supported by research: studies show that 600 mcg chromium + 2 mg biotin daily can positively influence blood sugar regulation.	Bioanalyst
Gymnema’s traditional use is backed by some small-scale clinical / preclinical evidence for reducing sugar absorption and supporting insulin. (MD/Process reference)	Sage Journals
The “blood sugar drain” concept (kidney-based glucose filtration) is more theoretical and marketing-driven, rather than a widely accepted clinical paradigm. Some reviewers question whether this “SG2 clog” mechanism is well-established in human physiology.	ScienceDirect

Pros and Cons

---

Pros	Cons
✔ Targets an underlooked mechanism (kidney glucose filtration) rather than just insulin	✖ The “blood sugar drain” theory is not universally accepted in mainstream medical research
✔ Contains Delphinol®, a research-backed maqui berry extract	✖ No large independent clinical trials on GlucoBerry as a finished formula
✔ High dose of gymnema leaf (400 mg), according to label	✖ High chromium dose (600 mcg) — could risk side effects or interactions for some people
✔ Strong nutrient support: chromium + biotin for glucose metabolism	✖ Biotin dose (2 mg) is very high; may affect lab tests or interact with other B-vitamin supplements
✔ Clean formulation: non-GMO, vegetarian capsules	✖ Gymnema’s effects may vary person-to-person; not a guaranteed “sweet crush” for everyone
✔ Long “risk-free” trial (180-day money-back guarantee)	✖ Results may take weeks to months, per manufacturer
✔ Doctor-formulated (Dr. Mark Weis, MD) — gives credibility	✖ More expensive than very basic supplements that use only chromium or gymnema

Who Is It For?

---

Best For	Avoid If
People who want to support blood sugar through kidney function, not just insulin.	You are on diabetes medications (especially those that lower blood sugar), unless cleared by a doctor.
Those who have mild to moderate glucose elevation and want a natural supplement.	You have kidney disease or impaired renal function — because the supplement targets renal glucose processes.
Users who like fruit-based antioxidant support (maqui berry).	You are pregnant or breastfeeding (safety in these groups not clearly established).
Individuals who are okay with one capsule daily and having “invested” time to see benefits.	You prefer formulations with more aggressive insulin-sensitising herbs or berberine-style compounds.
People who value a long guarantee period — good for trying safely.	You don’t want to wait — this is a support supplement, not a rapid “drop your sugar now” fix.

✅ If you’re looking for a unique, kidney-focused, doctor-formulated supplement that supports sugar filtration (not just insulin), GlucoBerry offers a novel and scientifically informed approach — try it risk-free with the 180-day guarantee.

IX.)  Zenith Labs Blood Sugar Premier

---

Company:  Zenith Labs
Owners:  Dr. Ryan Shelton, ND.
Based In:  USA
Rating: 

Website:  https://zenithlabs.com/product/blood-sugar-premier/

How Much To Buy:  $49.00 1 Bottle, $117 3 Bottles, $198 for 5 Bottles – Further Saving With Subscribe and Save.

About Blood Sugar Premier:

Blood Sugar Premier is a herbal-based glucose support supplement from Zenith Labs, formulated by Dr. Ryan Shelton, ND.
The formula focuses on three key ingredients — berberine, curcumin extract, and piperine — inspired by traditional Chinese herbal approaches to metabolic balance. It is marketed to support healthy blood sugar, insulin efficiency, and inflammation control.

Unlike many multi-ingredient blends, Blood Sugar Premier takes a minimalist, focused formulation approach, aiming for targeted support rather than broad-spectrum supplementation.

Ingredients:   

Berberine hydrochloride, Curcumin (turmeric root extract), BioPerine® (piperine / black pepper extract), Vitamin C (ascorbic acid), Calcium, Vitamin D3 (cholecalciferol), Vitamin B3 (niacin), Vitamin B6 (pyridoxine), Magnesium, Zinc, Chromium (as chromium picolinate), Fenugreek, Gymnema leaf, American Ginseng root extract, Button Mushroom (Agaricus bisporus), Alpha-lipoic acid (ALA), Cinnamon Bark, Bitter Melon, Garlic Powder, Milk Thistle, Holy Basil leaf extract, Resveratrol (from Japanese knotweed), Vanadium (as vanadyl sulfate)

How It Works:

✅ Berberine

Berberine is the star compound and may help:

• Activate AMPK, the metabolic “master switch”
• Support insulin sensitivity
• Improve cellular glucose uptake
• Reduce liver glucose production

AMPK activation is the same mechanism through which exercise and metformin influence glucose metabolism.

✅ Curcumin (Turmeric Extract)

Curcumin may:

• Support healthy inflammatory responses linked to metabolic dysfunction
• Help regulate fat metabolism
• Provide antioxidant support that may protect pancreatic beta cells

However, curcumin alone has low bioavailability — which is why piperine is included.

✅ Piperine (Black Pepper Extract)

Piperine increases absorption of curcumin and other compounds, potentially making the formula more effective.

Zenith Labs suggests that the berberine + curcumin + piperine trio helps maintain normal glucose and inflammatory signaling pathways, especially after meals.

Research Summary

---

Research	Source
Berberine: Strong evidence for improving insulin sensitivity, lowering fasting glucose, and reducing liver glucose output.	Journal of Translational Medicine
Curcumin: Studies show anti-inflammatory effects, and some research suggests curcumin can help regulate blood sugar in metabolic syndrome contexts.	NIH
Piperine: Known to enhance absorption of curcumin; some early studies suggest potential metabolic benefits.	NIH
The official product page references several peer-reviewed studies and includes links to PubMed.	Zenith Labs

Pros and Cons

---

Pros	Cons
✔ Scientifically grounded core trio: Berberine + Curcumin + Piperine is a well-thought-out combination.	✖ No large RCTs on the exact formula: As with many supplements, the product hasn’t been tested in a big clinical trial as-is.
✔ High-quality manufacturing: Produced in cGMP-certified facility per Zenith Labs.	✖ Potential interactions: Berberine, curcumin, and piperine can interact with medications (especially diabetes drugs).
✔ Supports multiple metabolic pathways: Not just insulin — also inflammation and fat-accumulation around the pancreas.	✖ Possible side-effects: Reported side effects (from user reviews) include dizziness (possibly from blood pressure drop) and allergic reactions.
✔ 180-day money-back guarantee: Very generous, reduces risk for the buyer.	✖ Not a substitute for prescription medication: The company explicitly warns this is a support supplement, not a treatment.
✔ Easy to take: Just 1 capsule twice a day with food.	✖ Cost: Depending on where you buy, long-term use may be moderately expensive.
✔ Vegan-friendly (mostly): According to reviews, the product lacks common allergens (though double check specific batch info).	✖ Effect may take time: According to the official site, many users need weeks to months to notice benefits.

Who Is It For?

---

Best For	Avoid If
People who want a natural, doctor-formulated supplement for blood sugar support.	You are on prescription blood sugar-lowering medications (unless approved by your healthcare provider).
Someone who is already reasonably healthy but wants to prevent spikes or support insulin sensitivity.	You are pregnant or breastfeeding — limited data on safety for curcumin at high doses.
Users willing to take the supplement consistently for several months to evaluate impact.	You have a sensitivity to pepper or piperine.
People who prefer a relatively simple, powerful core formula, instead of very broad multi-herb blends.	You have very low blood pressure — berberine or piperine might affect vascular tone.
Those who want inflammation support alongside sugar regulation.	You want a supplement that replaces your medical regimen — this is for support, not cure.

Explore Zenith Labs Blood Sugar Premier for a simplified, absorption-friendly blood sugar support option.

X.)  BrainMD Balance My Blood Sugar

---

Company:  BrainMD
Owners:  Dr. Daniel Amen
Based In:  USA
Rating:  4.5 Stars according to BrainMD website

Website:  BrainMD.com

How Much To Buy:  $35.00 1 Bottle. Free shipping on all subscriptions & US orders over $75*

About BrainMD Balance My Blood Sugar

Balance My Blood Sugar is a supplement from BrainMD, founded by Dr. Daniel Amen. It’s specifically designed to support metabolic health, stable glucose levels, and brain function, with a formula tailored to reduce blood sugar spikes, curb cravings, and improve mental clarity.

Ingredients:   Chromium, Biotin, Berberine HCL, Gymnema Sylvestre Extract, GlucoVantage DHB, Trans-Reservatrol, Veggie Capsules

How It Works

• Trans-Resveratrol: Included for its dual role — helps support healthy insulin levels and provides brain health benefits (resveratrol is often linked to anti-ageing and cognitive support).
• GlucoVantage® (Dihydroberberine): This is the core ingredient — a highly bioavailable form of berberine that BrainMD says is 34× more bioavailable than standard berberine. It supports glucose metabolism and may smooth out post-meal spikes.
• Berberine HCl: Works alongside GlucoVantage® to support insulin functioning and glucose balance.
• Gymnema Sylvestre Extract: Known as the “sugar destroyer,” it may reduce glucose absorption in the gut and help curb sugar cravings.
• Chromium + Biotin: These micronutrients help enhance insulin activity and support efficient glucose metabolism, contributing to more stable energy.

Research Summary

---

Research	Source
BrainMD’s own product page confirms the use of GlucoVantage®, which is a dihydroberberine (a berberine derivative) selected for its strong bioavailability.	BrainMD
Standard berberine (HCl): well studied for improving insulin sensitivity and reducing glucose levels — used here in a dual form to potentially increase effectiveness.	Medical News Today
Gymnema Sylvestre: traditionally used to regulate sugar absorption; some clinical and preclinical studies support its role in reducing glucose uptake.	Sage Journals
Chromium + Biotin: common insulin-support micronutrients; chromium helps with glucose uptake, biotin supports cellular metabolism.	Bioanalyst
Resveratrol: has been researched for its metabolic effects and potential neuroprotective / anti-inflammatory roles, though the evidence for glucose-lowering is modest in humans.	Nature.com

Pros and Cons

---

Pros	Cons
✔ Uses a very bioavailable form of berberine (GlucoVantage®), which may reduce typical gastrointestinal issues.	✖ The “blood sugar support” is supportive, not therapeutic; not a replacement for glucose-lowering medication.
✔ Combines glucose support with brain-health ingredients, aligning with BrainMD’s “brain + body” wellness model.	✖ High chromium content (400 mcg) and biotin (300 mcg) could be problematic for some individuals / may interact with medications.
✔ Addresses multiple mechanisms: insulin sensitivity, sugar absorption, and micronutrient support.	✖ Results may take weeks; not a “quick fix.”
✔ Includes chromium + biotin, which are well-recognized metabolic support nutrients.	✖ Dihydroberberine (GlucoVantage) is less studied in long-term human trials than standard berberine.
✔ Designed by a reputable company (BrainMD) — gives credibility.	✖ Some users may experience side-effects typical of berberine (digestive discomfort).
✔ Comes in a manageable dose: 2 capsules per serving (per BrainMD supplement facts).	✖ As a brand, BrainMD has mixed user reviews for its subscription practices.

Who Is It For?

---

Best For	Avoid If
People who want to support their blood sugar and brain function simultaneously.	You’re on insulin or strong glucose-lowering medication without medical supervision.
Those who experience post-meal glucose spikes and want a more bioavailable berberine.	You have sensitivity to chromium or biotin, or you take other high-dose B-vitamin supplements.
Individuals looking to stabilise cravings and maintain more consistent energy.	You’re pregnant / breastfeeding (safety of bioactive berberine forms is not well-studied in these populations).
Users who are comfortable using supplements for months to evaluate metabolic effects.	You’re expecting overnight, dramatic blood sugar reductions — this is a metabolic support supplement, not a drug.
Anyone already familiar with BrainMD’s supplement philosophy / brand trust.	You dislike subscription-based supplement brands (if you’re concerned about renewals).

✅ A smart supplement choice for anyone who wants to combine metabolic support with cognitive clarity — especially useful for stabilising glucose, reducing cravings, and supporting brain health. Visit the BrainMD website HERE<<

In Conclusion

---

Choosing the right blood sugar support supplement can feel overwhelming — especially with so many overhyped products on the market. The key is sticking to clinically studied ingredients, transparent dosing, reputable brands, and realistic expectations.

If you want a proven starting point:

Pair supplements with a balanced diet, movement, stress management, and consistent monitoring — and assess results over 8–12 weeks.