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Updated for 2025 — If you’re looking for an honest and up-to-date BiOptimizers Microbiome Breakthrough Review, you’re in the right place. Formerly known as Leaky Gut Guardian, this powerful gut-repair supplement from BiOptimizers has been rebranded and refined to better reflect its broader focus on microbiome health. The formula still features the same trusted blend of IgY Max®, probiotics, and prebiotics — now in a refreshed design that supports gut lining integrity, digestion, and immune function. In this review, we’ll explore what’s changed, what’s stayed the same, and whether Microbiome Breakthrough is still worth your investment in 2025.
In this review, we’ll explore what’s new, how it works, the key ingredients, and whether it’s worth trying if you’re looking to heal your gut naturally.
Leaky gut (or intestinal permeability) happens when the walls of your intestines develop tiny gaps. When that happens, toxins, bacteria, and undigested food can leak into your bloodstream.
Common symptoms include:
Eczema and acne
Fatigue and brain fog
Bloating and gas
Headaches
Left untreated, leaky gut can trigger inflammation, autoimmune issues, and nutrient malabsorption — all things Microbiome Breakthrough is designed to help support.
Now, what is this product and how is this any better than anything else currently on the market? Let’s explore what makes this product so good (or bad?).
The star ingredient in Microbiome Breakthrough is IgY Max®, a patented form of immunoglobulin yolk extract (IgY) derived from eggs. It works by binding to harmful bacteria and toxins in the gut, helping prevent them from damaging the intestinal lining. Studies suggest it may significantly reduce intestinal inflammation and support a healthier gut barrier.
2. Probiotic Blend
The formula includes several probiotic strains designed to restore microbial balance and promote smoother digestion. Probiotics help crowd out bad bacteria, improve nutrient absorption, and enhance immune resilience.
3. Prebiotic Inulin
Inulin serves as food for good bacteria, supporting their growth and stability within the gut microbiome.
You might also enjoy our guide on Detox Food Ideas for Losing Weight, which includes gut-cleansing ingredients that naturally support microbiome balance.
4. Collagen Peptides
Collagen provides amino acids that help repair the gut lining and improve intestinal wall integrity — a crucial step in reducing “leakiness.”
Bioptimizers Microbiome Breakthrough Review (Updated for 2025)
Microbiome Breakthrough (formerly Leaky Gut Guardian / Biome Breakthrough)
Manufactured By:
Bioptimizers
Created By:
Wade Lightheart and Matt Gallant
Website:
Visit BiOptimizers Official Store »
Brief Description:
Gut Repair & Microbiome Support Powder
Ingredients:
IgYMax, Lactobacillus Probiotics, Organic Inulin Prebiotic Fiber, and Bovine Bone Broth & Collagen (In The Carnivore Chocolate formula)
Flavours:
Chocolate and Vanilla
Things To Note:
✅ Trusted Company ✅ Reputable Brand ✅ Vegetarian Option Available ✅ 365 Days Satisfaction Guarantee (1 Bottle)
Do I Recommend:
✅ Yes — if you’re okay with egg-based ingredients (not vegan-friendly)
FTCDisclosure:
Please note that I am an affiliate of Bioptimizers. This post contains my affiliate links and if you use one of these links and it leads to you making a purchase it is very likely I will receive a commission. This will not make any difference to the price you will normally pay.
Please contact me at chivs86@dynamicideas4life.com if you’d like more information.
Health Disclaimer:
Just to make this clear I am not a doctor or qualified medical professional. Information shared within this post including my own views and opinions is based on my online research and not scientific facts. This information should not replace that from professionals such as doctors or medical practitioners.
What Is Microbiome Breakthrough?
Microbiome Breakthrough (formerly Leaky Gut Guardian) is a gut health powder from BiOptimizers, a trusted brand known for its science-backed digestive supplements. It aims to repair the gut lining and balance the microbiome using a combination of IgY Max® (immunoglobulin egg powder), prebiotics, probiotics, and collagen peptides.
The supplement comes in two flavours — Chocolate and Vanilla — both naturally sweetened and designed to mix easily with water, smoothies, or shakes.
Quick Facts
Brand: BiOptimizers
Product Type: Gut Repair & Microbiome Support Powder
Main Ingredients: IgY Max®, Probiotic Blend, Inulin (Prebiotic Fiber), Collagen
As mentioned already there are two different flavours. One for carnivores (meat-eaters) and one for vegetarians. Just quickly I will summarize each below;
Benefits of BiOptimizers Microbiome Breakthrough
Users report several key benefits with consistent use:
Strengthened gut lining and reduced digestive discomfort
Improved bowel regularity and less bloating
Enhanced nutrient absorption and energy
Healthier immune response
Clearer skin and reduced food sensitivities
Many notice results within a few weeks, though optimal results typically appear after 1–2 months of daily use.
According to BiOptimizers, the new name Microbiome Breakthrough better represents the product’s broader focus on the entire gut microbiome, not just the intestinal lining. While the core formula remains similar to the original, this refreshed branding emphasizes the product’s role in nurturing beneficial bacteria, improving digestion, and enhancing nutrient absorption.
So, if you were a fan of Leaky Gut Guardian, rest assured—Microbiome Breakthrough is still the same trusted supplement, just with a new name and a sharper identity.
Is BiOptimizers Microbiome Breakthrough Safe?
Yes. The product is made with natural, non-GMO ingredients and contains no artificial colours, preservatives, or sweeteners. However, because it contains egg-derived IgY Max®, it is not suitable for vegans or those with egg allergies.
As always, anyone with medical conditions or on medication should check with a healthcare professional before starting a new supplement.
About The 2 Different Flavours
Flavour #1 – Carnivore Chocolate
So this first flavour is Carnivore Chocolate. It is made with Ecuadorian Raw Cocoa, Bovine Collagen and Bone Broth as well as the usual Ingredients such as IgYMax Egg Powder and the Probiotic Blend.
Basically, “bovine bone broth is a rich source of essential fatty acids, amino acids, vitamins, and minerals”.
Plus also Bioptimizers say this version has added benefits to the vegetarian one because bone broth is a natural source of glutamine and gelatin. And Bovine Collagen can help to prevent damage to the intestinal lining.
or if you prefer… let’s take a look at the alternative ▶
Flavour #2 Vegetarian Vanilla
For anyone that doesn’t like the idea of drinking a shake or smoothie with bovine collagen and bone broth or even Chocolate flavor, this is the vegetarian alternative.
Vegetarian Vanilla is not vegan as it still contains IgY Max hyper Immunized Egg powder but if you are vegetarian and you aren’t bothered about the egg powder then look no further.
If you look on the Bioptimizers website on the about page you can see that Bioptimizers has partnered with Burch University in Bosnia where they have multiple scientists with PhDs working in their probiotics lab.
It certainly does help paint a very interesting picture. Although, one of the big questions surrounding MicrobiomeBreakthrough is about one of its main ingredients IgYmax – which is a patented blend of Immunized Egg Powder.
This ‘kind of’ sounds a bit off-putting to me. Mostly because I don’t like eggs but I’ve done some research on this and it’s actually something that has found itself to have quite a reputation for what it can do.
You may have heard of this ingredient before. It’s been around for quite some time already and it’s definitely very popular amongst some that have used this.
Especially for its effects on Immune health. But…
Pros and Cons
Pros
Clinically supported IgY Max® ingredient
Combines prebiotics, probiotics, and gut-lining nutrients
Supports both gut repair and microbiome balance
Backed by BiOptimizers’ 365-day money-back guarantee
Available in two flavours
Cons
Contains egg (not vegan-friendly)
Slightly higher price point than standard probiotics
Requires consistent use for best results
How to Use Microbiome Breakthrough
Mix one scoop with 8–12 oz of water or your favourite drink. It can be taken any time of day, though many users prefer mornings before breakfast or between meals for best absorption. Both flavours blend smoothly and can also be added to smoothies or protein shakes.
Who Should Try It
Microbiome Breakthrough may be beneficial for:
Those struggling with digestive issues, bloating, or IBS
People with symptoms of leaky gut
Anyone looking to support their immune health
Individuals who have taken antibiotics or have poor gut balance
If you’ve tried traditional probiotics without lasting improvement, this formula’s gut-lining repair + microbiome balance approach could offer a more complete solution.
What Is Immunized Egg Powder (IgY Max)?
One of the standout ingredients in Microbiome Breakthrough is IgY Max®, a patented form of hyperimmunized egg powder.
It’s made by immunizing hens to produce specific antibodies (IgY) that target harmful bacteria in the gut. These antibodies are then extracted from the egg yolk and added to the formula.
Research shows IgY Max® can help reduce leaky gut markers like Zonulin by up to 95%, support the immune system, and promote a healthier gut microbiome.
Stevia Extract (sweetener), vanilla, or chocolate extract (depending on which you choose).
*Note: I have mentioned this already but the difference between the Vanilla and Chocolate Microbiome Breakthrough is chocolate contains 2 extra ingredients – Bovine Broth and Bovine Collagen.
So, IgYmax is of course the main ingredient. This works by triggering the immune system to replace unhealthy bacteria with beneficial bacteria (probiotics) and has been clinically shown to reduce the leaky gut marker Zonulin by 95%.
*note Zonulin is a protein that affects intestinal permeability as it modulates the tight junctions between cells in the digestive tract. Reducing Zonulin’s presence within the gut environment according to scientific data will go some way to fixing leaky guts.
Plus it is also worth mentioning that IgYmax can also improve the gut lining’s ability to break down histamine, which itself can be problematic given that it can cause gut inflammation.
Now, as well as this you also have probiotics and prebiotics. Forming new colonies of these bacteria this works alongside the IgYmax to help the gut’s natural ability to cleanse itself of detrimental bacteria and pathogens.
The rest of the ingredients are really just there for the flavoring. Stevia extract, vanilla/chocolate flavoring, etc. These are really just for the taste.
For anyone in doubt, I think you can tell a lot about the legitimacy of Microbiome Breakthrough just by the background of Bioptimizers. They are a company that was first established in 2004, they have helped thousands of people worldwide become healthier and there are plenty of reviews to back this up. Look up MassZymes and P3OM to see just some of these reviews.
If you look on Trustpilot this one place and also actually even though they never seem to ever have any products there in stock Bioptimizers have their own Amazon store which itself has plenty of reviews.
Just look at Bioptimizers and all their other products. The reviews are amazing and there are many happy repeat customers. You also get a full 365-day satisfaction guarantee with every order.
The price is maybe not for everyone but you should find that Bioptimizers as a company is definitely LEGIT.
Although I think really the main question that needs to be asked before you decide to buy is this…
I shared some of the symptoms of a Leaky Gut at the beginning of the article. Skin conditions such as eczema, acne plus things like bloating, gas, and fatigue can all be signs that you have a leaky gut but just to elaborate further.
Here are some of the indicators that you could have Leaky Gut Syndrome.
Burning feeling like you have Stomach Ulcers.
Diarrhoea
Painful Indigestion. This is caused by the loss of intestinal mucosa.
Bloating/Gas. From the fermentation of bacterial overgrowth.
Loss of energy/fatigue. As a result of fewer nutrients being absorbed.
There is no actual test for Leaky Gut Syndrome but for Intestinal Permeability some methods of testing that are thought to work include;
By Taking a Blood or Urine Test,
Tissue Biopsy or
Confocal Endomicroscopy
These are not definitive tests but if you really want to get technical this is what a doctor might suggest.
Although, the best way to decide whether a supplement like this is for you is probably by whether you have any of the symptoms in the 5 points above.
However, another thing to note is that according to Bioptimizers most people have some degree of Leaky gut they just don’t realize it.
With each 150 g tub of Microbiome Breakthrough, you get a nutrient-rich powder blend designed to soothe and support your digestive tract. The formula includes a combination of probiotics, prebiotics, immunoglobulins, and gut-friendly nutrients that work together to:
Reinforce the gut barrier and reduce intestinal permeability (“leaky gut”)
Restore a healthy balance of gut bacteria
Calm digestive inflammation and discomfort
Support immune function and nutrient absorption
Promote clearer skin, improved energy, and overall digestive well-being
Microbiome Breakthrough can be mixed easily into water, smoothies, or non-dairy milk for a creamy, lightly sweet drink. Many users find it fits seamlessly into their morning or post-meal routine — especially when used consistently over several weeks.
*Note if you click on the image above you will be redirected to the Microbiome Breakthrough website where you can choose from the two different flavors.
*Don’t forget to use Discount Code 13586 at checkout for 10% off
Who Is Microbiome Breakthrough For?
Anyone with Leaky Gut Syndrome, Intestinal Permeability, or anyone that suspects they might have either condition should consider this product. This is definitely coming from a company with a good reputation but also really anyone that just wants to maximize their gut health and to further reinforce their gut lining may also want to consider this product.
I will share some other products as well (please keep reading) but really anyone that wants a guaranteed solution for better gut health Bioptimizers Microbiome Breakthrough really should be worth considering.
Although, like any dietary supplement, of course, it is advised to speak to a doctor first, or even if you really want to you can contact Bioptimizers through their website to speak to them about your gut health issues and they can tell you what they themselves recommend.
Other Leaky Gut Supplements For Sale
*Please note I have not researched any of these products. These are just some I have found online.
Product Name
Price
Vegan Friendly
Ingredients
Where To Buy
Amen Leaky Gut +
N/A
Yes
Glutamine, Zinc, Organic Turmeric, Licorice Root, and Marshmallow Root along with a blend of probiotics (10 Billion CFU)
Final Verdict: Is BiOptimizers Microbiome Breakthrough Really Worth It?
Upon reading through the Bioptimizers Microbiome Breakthrough home page there are some points that I felt were quite interesting.
Like It says that “Harvard doctors say most people all have some degree of Leaky Gut Syndrome”.
It kind of seems a bit crazy but then it continues to say that – processed food, contaminated tap water, too much sugar, antibiotics, gluten, casein, and heavy metals from food packaging can all worsen the gut lining.
Really it’s not hard to see why so many people are affected by conditions such as Leaky Gut because all the above are very real issues affecting the human race on a very large scale.
Just gluten for instance – whether you are gluten intolerant or not this alone can spike zonulin levels. Casein which is the protein in milk this too can cause leaks. Mercury from dental fillings and seafood, arsenic from white rice, cadmium, and lead from air pollution…
and the list goes on.
So many things can cause gut problems and what the guys at Harvard say they are likely, not wrong.
Many of us likely have some level of Leaky Gut and we don’t even realize it.
In fact, till we actually treat this condition we may not even notice until we actually take something like Microbiome Breakthrough and notice the difference afterward.
1.) Marcelo Campus MD: What Is Leaky Gut and What Does It Mean For You? 2.) Kayla McDonnell RD: https://www.healthline.com/nutrition/bone-broth 3.) J Chiropr Med. 2004 Winter; 3(1): 12–14. : Hyperimmune egg powder for the treatment of IBS 4.) https://www.webmd.com/vitamins/ai/ingredientmono-1130/hyperimmune-egg 5.) https://my.clevelandclinic.org/health/drugs/16386-antibiotics 6.) Dr. Michael Ruscio: https://drruscio.com/everything-you-need-to-know-about-histamine-intolerance/
Microbiome Breakthrough is a gut repair and microbiome support powder by BiOptimizers. It combines IgY Max® (immunoglobulin egg powder), probiotics, and prebiotics to help strengthen the gut lining and support digestion and immunity.
2. Is Microbiome Breakthrough vegan or vegetarian friendly?
It’s not vegan, as it contains IgY Max® made from egg powder. However, there is a vegetarian vanilla version that excludes bovine collagen and bone broth.
3. How long does it take to see results?
Most users report noticeable digestive improvements within 2–4 weeks when taken consistently. Optimal results often occur after 6–8 weeks.
4. What’s the difference between the Chocolate and Vanilla versions?
The Chocolate version (Carnivore) includes bovine collagen and bone broth for added gut-lining support, while the Vanilla (Vegetarian) version excludes those ingredients.
5. Does BiOptimizers offer a guarantee?
Yes. BiOptimizers offers a 365-day satisfaction guarantee on all their products, including Microbiome Breakthrough.
Alex Chivers writes about natural health, nutrition, and lifestyle wellness at Dynamic Ideas 4 Life. His mission is to help readers discover practical, evidence-based ways to feel better, live healthier, and take control of their wellbeing — naturally.
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6 Comments
Hi Alex,
Thanks for this comprehensive review of Leaky Gut Guardian. So much is being said about leaky gut everyday, but it was really nice to read an article about it rather than the advertorial as that direct you to a 40 minute long video!! It is also good to know that there are tests for intestinal permeability because bloating and fatigue could be signs of other things as well.
Still unsure about the method used for the egg powder- IgY hens are immunized against specific bacteria and diseases. As you rightly concluded, it would be good to have an idea of which bacteria and diseases. If the product is approved for sale on the market, I think it is probably safe. If I had to use this I would go with the chocolate flavor.
Hi Ceci, Yes so this is something I’ve wanted to cover for a while now. I’m glad you found it helpful. There are tests for intestinal permeability but I think the symptoms alone can be quite apparent. It is said that many of us suffer from some degree of leaky gut. Gluten and Casein people are always consuming and these are two of the most difficult proteins to digest. It is said that just this, people consuming too much wheat and dairy is one very common factor for leaky gut. Plus there surely are plenty others I would suspect – anything that causes GI Inflammation I think can be responsible.
As for IGY Hens I still need to look into this further. I think IgY Max which is the patented blend of hyperimmunized egg powder inside Leaky Gut Guardian has its own website so maybe I can reach out to them there but I would guess e.coli s one of the main things – but then I have heard a lot of good things about it as an alternative to antibiotics because it doesn’t attack healthy gut bacteria. I mean for what its worth I think if it can solve digestive issues that are actually causing people problems then why not? I would also go with the chocolate flavour I think but then I would say vegan supplements always seem more appealing to me as they seem more natural.
Hi Alex
This is such a detailed review of Leaky Gut Guardian and well explained. A leaky gut can be a terrible disease and the symptoms are not pleasant at all. In our Clinic, we always encourage people to look into changing their diet as well which can be a good starting point as well as using supplements.
It looks like the Leaky Gut Guardian has all the right ingredients. But how safe is it? can you buy over the counter?
Hi Angee, Thanks I’m glad you like it. Yes, Leaky Gut can be very troublesome in some cases this can lead to immunodeficiency which is the 3rd biggest killer in the world. In less serious cases it can be responsible for inflammation, bloating, gas and other digestive discomforts. Changing diet is important probiotic foods and prebiotic foods are good options to consider. Leaky Gut Guardian actually contains both. Also, you ask if this is safe. Yes it is definitely safe you just not to research the company to see that they will tell you this – a lot of care goes into making these products [CHECK OUT THEIR WEBSITE) – they have their own probiotics lab in Bosia university. You can not buy OTC only from the Bioptimizers website and on occasion from Amazon.
HI Alex,
I am not familiar with the leaky gut syndrome, and really didn’t know much about it until I read you review. It sounds like many people could be suffering from this problem and not even know it. Even in this day and age, the medical community does not have all the answers. I am sure their will be a test that confirms this diagnosis in the future.
Like you, I am not a vegan, but I do like to avoid the non-vegan products because of some animals being destroyed to produce the products. In this case though, I would be ok with it being developed using eggs. But, I still have some concerns about the immunizations. Are they using antibiotics? If so, then that would be a problem with me. Thank you, for sharing such an in-depth review on Leaky Gut Guardian.
Hi Chas, Thanks for commenting. Yes, I never really knew much about what leaky gut is prior to researching this product but yes it is quite a widespread problem due to all the toxic shite that is in people’s food and drink. I think the test you are on about I’m not sure how it would work – I think maybe the only way to really check is with a microscope/x-ray to check the actual stomach lining for holes although generally there are quite a range of symptoms which might help you decide if you want to consider this as a treatment. I mean it is probably something that has the potential to help many people with digestive discomfort. It is something that probably wouldn’t be a waste even if you didn’t have a leaky gut as the probiotics and prebiotics inside would still be beneficial to overall gut health.
Also definitely agree about the vegan part – it doesn’t bear thinking about what happens to animal for things like gelatin and collagen to be extracted. I could really go on here. As for the eggs and the hyperimmunized egg powder that is inside the supplements I will need to reach out to bioptimizers I think to see if they can tell me more.
Hi Alex,
Thanks for this comprehensive review of Leaky Gut Guardian. So much is being said about leaky gut everyday, but it was really nice to read an article about it rather than the advertorial as that direct you to a 40 minute long video!! It is also good to know that there are tests for intestinal permeability because bloating and fatigue could be signs of other things as well.
Still unsure about the method used for the egg powder- IgY hens are immunized against specific bacteria and diseases. As you rightly concluded, it would be good to have an idea of which bacteria and diseases. If the product is approved for sale on the market, I think it is probably safe. If I had to use this I would go with the chocolate flavor.
Ceci
Hi Ceci, Yes so this is something I’ve wanted to cover for a while now. I’m glad you found it helpful. There are tests for intestinal permeability but I think the symptoms alone can be quite apparent. It is said that many of us suffer from some degree of leaky gut. Gluten and Casein people are always consuming and these are two of the most difficult proteins to digest. It is said that just this, people consuming too much wheat and dairy is one very common factor for leaky gut. Plus there surely are plenty others I would suspect – anything that causes GI Inflammation I think can be responsible.
As for IGY Hens I still need to look into this further. I think IgY Max which is the patented blend of hyperimmunized egg powder inside Leaky Gut Guardian has its own website so maybe I can reach out to them there but I would guess e.coli s one of the main things – but then I have heard a lot of good things about it as an alternative to antibiotics because it doesn’t attack healthy gut bacteria. I mean for what its worth I think if it can solve digestive issues that are actually causing people problems then why not? I would also go with the chocolate flavour I think but then I would say vegan supplements always seem more appealing to me as they seem more natural.
Hi Alex
This is such a detailed review of Leaky Gut Guardian and well explained. A leaky gut can be a terrible disease and the symptoms are not pleasant at all. In our Clinic, we always encourage people to look into changing their diet as well which can be a good starting point as well as using supplements.
It looks like the Leaky Gut Guardian has all the right ingredients. But how safe is it? can you buy over the counter?
Cheers, Angee
Hi Angee, Thanks I’m glad you like it. Yes, Leaky Gut can be very troublesome in some cases this can lead to immunodeficiency which is the 3rd biggest killer in the world. In less serious cases it can be responsible for inflammation, bloating, gas and other digestive discomforts. Changing diet is important probiotic foods and prebiotic foods are good options to consider. Leaky Gut Guardian actually contains both. Also, you ask if this is safe. Yes it is definitely safe you just not to research the company to see that they will tell you this – a lot of care goes into making these products [CHECK OUT THEIR WEBSITE) – they have their own probiotics lab in Bosia university. You can not buy OTC only from the Bioptimizers website and on occasion from Amazon.
HI Alex,
I am not familiar with the leaky gut syndrome, and really didn’t know much about it until I read you review. It sounds like many people could be suffering from this problem and not even know it. Even in this day and age, the medical community does not have all the answers. I am sure their will be a test that confirms this diagnosis in the future.
Like you, I am not a vegan, but I do like to avoid the non-vegan products because of some animals being destroyed to produce the products. In this case though, I would be ok with it being developed using eggs. But, I still have some concerns about the immunizations. Are they using antibiotics? If so, then that would be a problem with me. Thank you, for sharing such an in-depth review on Leaky Gut Guardian.
Hi Chas, Thanks for commenting. Yes, I never really knew much about what leaky gut is prior to researching this product but yes it is quite a widespread problem due to all the toxic shite that is in people’s food and drink. I think the test you are on about I’m not sure how it would work – I think maybe the only way to really check is with a microscope/x-ray to check the actual stomach lining for holes although generally there are quite a range of symptoms which might help you decide if you want to consider this as a treatment. I mean it is probably something that has the potential to help many people with digestive discomfort. It is something that probably wouldn’t be a waste even if you didn’t have a leaky gut as the probiotics and prebiotics inside would still be beneficial to overall gut health.
Also definitely agree about the vegan part – it doesn’t bear thinking about what happens to animal for things like gelatin and collagen to be extracted. I could really go on here. As for the eggs and the hyperimmunized egg powder that is inside the supplements I will need to reach out to bioptimizers I think to see if they can tell me more.